The GPM6A Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to Glycoprotein M6A, and GPM6A. This antibody recognizes Mouse, and Rat antigen. The GPM6A Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated has been validated for the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen.
Description
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor